Role of reactive oxygen species (ROS) in apoptosis induction.

Abstract

Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 2000 Nov;5(5):415-8 Authors: Simon HU, Haj-Yehia A, Levi-Schaffer F Abstract Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells. PMID: 11256882 [PubMed - indexed for MEDLINE]