Ruthenium polypyridyl peptide conjugates: Membrane permeable probes for cellular imaging

  • Neugebauer U
  • Pellegrin Y
  • Devocelle M
 et al. 
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Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru-R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for its permeablisation.

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  • Ute Neugebauer

  • Yann Pellegrin

  • Marc Devocelle

  • Robert J. Forster

  • William Signac

  • Niamh Moran

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