The search for the palmitoylethanolamide receptor

  • LoVerme J
  • La Rana G
  • Russo R
 et al. 
  • 74


    Mendeley users who have this article in their library.
  • 154


    Citations of this article.


Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-inflammatory effects of PEA were first characterized nearly 50 years ago, the identity of the receptor mediating these actions has long remained elusive. We recently identified the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-α), as the receptor mediating the anti-inflammatory actions of this lipid amide. Here we outline the history of PEA, starting with its initial discovery in the 1950s, and discuss the pharmacological properties of this compound, particularly in regards to its ability to activate PPAR-α. © 2005 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Epilepsy
  • Inflammation
  • Lipid
  • Pain
  • Palmitoylethanolamide
  • Peroxisome proliferator-activated receptor-alpha (PPAR-α)

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jesse LoVerme

  • Giovanna La Rana

  • Roberto Russo

  • Antonio Calignano

  • Daniele Piomelli

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free