Serglycin proteoglycan in hematologic malignancies: A marker of acute myeloid leukemia

  • Niemann C
  • Kjeldsen L
  • Ralfkiaer E
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 21


    Citations of this article.


Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • C. U. Niemann

  • L. Kjeldsen

  • E. Ralfkiaer

  • M. K. Jensen

  • N. Borregaard

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free