Serum leptin and ghrelin levels in response to methylprednisolone injection in healthy dogs

  • Yilmaz Z
  • Ilcol Y
  • Golcu E
  • 3

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Abstract

The aim of this study was to investigate the effects of methylprednisolone treatment on serum leptin and ghrelin levels in healthy dogs (n=40). After 14 h of fasting, the dogs were injected intramuscularly with saline (control group) or methylprednisolone (1, 5 or 10mg/kg). Blood samples were collected prior to (baseline) and 2, 3, 4, 8, 12 and 24h subsequent to the treatments. Serum leptin and ghrelin were measured by radioimmunoassay. The mean baseline serum leptin and ghrelin were 2.5+/-0.1 ng/mL (n=40) and 35.0+/-2.1 pg/mL (n=40), respectively. In the control dogs, serum leptin, but not ghrelin levels showed a significant fluctuation during the 24h observation period. Serum leptin increased significantly (p

Author-supplied keywords

  • Animals
  • Dogs/*blood
  • Female
  • Ghrelin
  • Glucocorticoids/*pharmacology
  • Hydrocortisone/blood
  • Leptin/*blood
  • Male
  • Methylprednisolone/*pharmacology
  • Peptide Hormones/*blood
  • Regression Analysis

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Authors

  • Z Yilmaz

  • Y O Ilcol

  • E Golcu

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