Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system

  • Roethig H
  • Zedler B
  • Kinser R
 et al. 
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Abstract

This randomized, controlled, forced-switching, open-label, parallel-group study in 100 adult male and female smokers of conventional cigarettes evaluated 8 biomarkers of tobacco smoke exposure. After baseline exposure determinations, adult smokers were switched to a second-generation electrically heated cigarette smoking system (EHCSS) for 8 days in a clinical setting. After 8 days of smoking the EHCSS biomarkers of exposure decreased by 43% to 85% compared to baseline. After correction for residual effects (carryover effects due to long elimination half-life and non-tobacco-confounding sources of exposure), reductions in exposure ranged from 59% to 97%. Results from this short-term clinical exposure study indicate that switching from a conventional cigarette to a second-generation electrically heated cigarette smoking system substantially reduced the exposure to several measured potentially harmful constituents of tobacco smoke.

Author-supplied keywords

  • Biomarkers
  • Controlled smoking
  • Exposure evaluation

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Authors

  • Hans J. Roethig

  • Barbara K. Zedler

  • Robin D. Kinser

  • Shixia Feng

  • Bettie L. Nelson

  • Qiwei Liang

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