Sleep Disordered Breathing in a High-Risk Cohort Prevalence and Severity across Pregnancy

  • Facco F
  • Ouyang D
  • Zee P
 et al. 
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Objective—The objective of this study was to determine the prevalence and incidence of sleep disordered breathing (SDB) in pregnancy among high-risk women. Study Design—This was a prospective, observational study. We recruited women with a body mass index (BMI) 30 ≥ kg/m2, chronic hypertension, pregestational diabetes, history of preeclampsia, and/or a twin gestation. Objective assessment of SDB was completed between 6 and 20 weeks and again in the third trimester. SDB was defined as an apnea–hypopnea index (AHI) ≥ 5, and further grouped into severity categories: mild (5–14.9), moderate (15–29.9) and severe (≥30). Subjects who had a normal AHI at the baseline (AHI < 5), but an abnormal study in the third trimester (AHI 5) were classified as having “new-onset” SDB. Results—A total of 128 women were recruited. In early pregnancy 21, 6 and 3% had mild, moderate, or severe SDB, respectively. These frequencies increased to 35, 7, and 5% in the third trimester (p < 0.001). About 27% (n = 34) experienced a worsening of SDB during pregnancy; 26 were cases of new-onset SDB, while the other 8 had SDB in early pregnancy that worsened in severity. The incidence of new-onset SDB was 20%. The majority of these new-onset cases were mild. Conclusions—SDB in early pregnancy is common in high-risk women and new-onset SDB occurs in 20% of these women.

Author-supplied keywords

  • pregnancy
  • sleep apnea
  • sleep disordered breathing

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  • Francesca L. Facco

  • David W. Ouyang

  • Phyllis C. Zee

  • William A. Grobman

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