Suppressor of cytokine signaling 1 (SOCS1) is an intracellular inhibitor of cytokine, growth factor, and hormone signaling. Socs1-/- mice die before weaning from a multiorgan inflammatory disease. Neonatal Socs1 -/- mice display severe hypoglycemia and hypoinsulinemia. Concurrent interferony gene deletion (Ifng-/-) prevented inflammation and corrected the hypoglycemia. In hyperinsulinemic clamp studies, however, Socs1-/- -Ifng-/- mice had enhanced hepatic insulin sensitivity demonstrated by greater suppression of endogenous glucose production compared with controls with no difference in glucose disposal. Socs1 -/-Ifng-/- mice had elevated liver insulin receptor substrate 2 expression (IRS-2) and IRS-2 tyrosine phosphorylation. This was associated with lower phosphoenolpyruvate carboxykinase mRNA expression. These effects were not associated with elevated hepatic AMP-activated protein kinase activity. Hepatic insulin sensitivity and IRS-2 levels play central roles in the pathogenesis of type 2 diabetes. Socs1 deficiency increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
CITATION STYLE
Jamieson, E., Chong, M. M. W., Steinberg, G. R., Jovanovska, V., Fam, B. C., Bullen, D. V. R., … Andrikopoulos, S. (2005). Socs1 deficiency enhances hepatic insulin signaling. Journal of Biological Chemistry, 280(36), 31516–31521. https://doi.org/10.1074/jbc.M502163200
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