Spasmogenic activity and acute toxicity of Yumijangquebo, a herbal laxative formulation

  • Ryu S
  • Park C
  • Hwang S
 et al. 
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Abstract

We evaluated the pharmacological properties and spasmogenic activities of Yumijangquebo™, a Korean herbal laxative formulation. Doses in the range 12-50 μg/ml induced a large spasmogenic effect in isolated guinea pig ileum, similar to that induced by acetylcholine. Pre-treating the tissue with atropine (0.2 μM) completely abolished the contractile effect of Yumijangquebo. The spasmogenic effect of Yumijangquebo and the inhibition of this effect by atropine suggest that a cholinergic mechanism is responsible for its effects. Yumijangquebo increased the gastrointestinal motility in ICR mice at doses between 10 and 37 mg/kg. Yumijangquebo exhibited higher activity than three other laxatives tested, which had activities about 85% of that of Yumijangquebo. In an acute toxicity study using Sprague-Dawley rats, the median lethal dose (LD50) of Yumijangquebo was greater than 2000 mg/kg, and we found no pathological changes in macroscopic examination by necropsy of rats treated with Yumijangquebo. We conclude that Yumijangquebo may be safely used as a herbal spasmogenic laxative agent. © 2005 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Acute toxicity test
  • Herbal laxative
  • Spasmogenic
  • Yumijangquebo

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Authors

  • Seung Duk Ryu

  • Chang Shin Park

  • Sung Yeoun Hwang

  • Yeong Chul Park

  • Woon Gye Chung

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