Stage specific kinetoplast DNA-binding proteins in Trypanosoma cruzi

  • Zavala-Castro J
  • Acosta-Viana K
  • Guzmán-Marín E
 et al. 
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Knowledge regarding kinetoplast DNA organization in all members of the Trypanosomatid family is incomplete. Recently, the presence of kinetoplast- associated proteins in condensing kDNA networks in Crithidia fasciculata has been described and a role for these proteins in the maintenance of these complex structures was suggested. To investigate the presence of protein components in Trypanosoma cruzi kinetoplast, we previously described seven epimastigote kinetoplast-associated proteins. We report here the existence of kinetoplast binding proteins in amastigote and trypomastigote stages of T. cruzi, which could bind both mini and maxicircles components with a stage specific elements for every infective form of the parasite. We propose three major classes of kinetoplast-associated proteins related to the basic processes of this intricate disc structure and suggest a possible function of these binding proteins in the T. cruzi mitochondrial DNA organization. (C) 2000 Elsevier Science B.V.

Author-supplied keywords

  • DNA organization
  • Kinetoplast DNA-binding proteins
  • Mitochondrial DNA
  • Trypanosoma cruzi

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  • Karla Y. Acosta-VianaUniversidad Autónoma de Yucatán, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi"

  • Jorge E. Zavala-Castro

  • Eugenia Guzmán-Marín

  • María Eugenia Rosado-Barrera

  • José Luis Rosales-Encina

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