Stage specific kinetoplast DNA-binding proteins in Trypanosoma cruzi

  • Zavala-Castro J
  • Acosta-Viana K
  • Guzmán-Marín E
 et al. 
  • 10

    Readers

    Mendeley users who have this article in their library.
  • 7

    Citations

    Citations of this article.

Abstract

Knowledge regarding kinetoplast DNA organization in all members of the Trypanosomatid family is incomplete. Recently, the presence of kinetoplast- associated proteins in condensing kDNA networks in Crithidia fasciculata has been described and a role for these proteins in the maintenance of these complex structures was suggested. To investigate the presence of protein components in Trypanosoma cruzi kinetoplast, we previously described seven epimastigote kinetoplast-associated proteins. We report here the existence of kinetoplast binding proteins in amastigote and trypomastigote stages of T. cruzi, which could bind both mini and maxicircles components with a stage specific elements for every infective form of the parasite. We propose three major classes of kinetoplast-associated proteins related to the basic processes of this intricate disc structure and suggest a possible function of these binding proteins in the T. cruzi mitochondrial DNA organization. (C) 2000 Elsevier Science B.V.

Author-supplied keywords

  • DNA organization
  • Kinetoplast DNA-binding proteins
  • Mitochondrial DNA
  • Trypanosoma cruzi

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Karla Y. Acosta-VianaUniversidad Autónoma de Yucatán, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi"

    Follow
  • Jorge E. Zavala-Castro

  • Eugenia Guzmán-Marín

  • María Eugenia Rosado-Barrera

  • José Luis Rosales-Encina

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free