Knowledge regarding kinetoplast DNA organization in all members of the Trypanosomatid family is incomplete. Recently, the presence of kinetoplast- associated proteins in condensing kDNA networks in Crithidia fasciculata has been described and a role for these proteins in the maintenance of these complex structures was suggested. To investigate the presence of protein components in Trypanosoma cruzi kinetoplast, we previously described seven epimastigote kinetoplast-associated proteins. We report here the existence of kinetoplast binding proteins in amastigote and trypomastigote stages of T. cruzi, which could bind both mini and maxicircles components with a stage specific elements for every infective form of the parasite. We propose three major classes of kinetoplast-associated proteins related to the basic processes of this intricate disc structure and suggest a possible function of these binding proteins in the T. cruzi mitochondrial DNA organization. (C) 2000 Elsevier Science B.V.
CITATION STYLE
Zavala-Castro, J. E., Acosta-Viana, K., Guzmán-Marín, E., Rosado-Barrera, M. E., & Rosales-Encina, J. L. (2000). Stage specific kinetoplast DNA-binding proteins in Trypanosoma cruzi. Acta Tropica, 76(2), 139–146. https://doi.org/10.1016/S0001-706X(00)00079-6
Mendeley helps you to discover research relevant for your work.