Stereocontrolled creation of adjacent quaternary and tertiary stereocenters by a catalytic conjugate addition

  • Li H
  • Wang Y
  • Tang L
 et al. 
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Abstract

Not too close for comfort: Practical chiral organocatalysts like that shown promote Michael addition reactions of a wide range of trisubstituted carbon nucleophiles to various nitroalkenes, often with nearly perfect stereoselectivity (>99% ee and >98:2 d.r.). In one step adjacent carbon- or heteroatom-substituted quaternary and tertiary stereocenters are generated from readily available starting materials.

Author-supplied keywords

  • Asymmetric catalysis
  • Cinchona alkaloids
  • Hydrogen bonding
  • Michael addition
  • Nitroalkenes

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Authors

  • Hongming Li

  • Yi Wang

  • Liang Tang

  • Fanghui Wu

  • Xiaofeng Liu

  • Chengyun Guo

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