Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

  • Watanabe Y
  • Gould E
  • McEwen B
  • 269

    Readers

    Mendeley users who have this article in their library.
  • 871

    Citations

    Citations of this article.

Abstract

The hippocampus is vulnerable to the damaging actions of insults such as transient ischemia and repetitive stimulation, as well as repeated exposure to exogenous glucocorticoids. This study investigated effects of a repeated psychological stressor, restraint, on the CA3 pyramidal neurons which are vulnerable to damage by repetitive stimulation. Repeated daily restraint stress for 21 days caused apical dendrites of CA3 pyramidal neurons to atrophy, while basal CA3 dendrites did not change. Rats undergoing this treatment were healthy and showed some adaptation of the glucocorticoid stress response over 21 days; however, stress reduced body weight gain by 14% and increased adrenal weight relative to body weight by 20%. Results are discussed in relation to the possible role of adrenal steroids and excitatory amino acids. © 1992.

Author-supplied keywords

  • Atrophy
  • Dendrite
  • Glucocorticoid
  • Hippocampus
  • Stress

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Yoshifumi Watanabe

  • Elizabeth Gould

  • Bruce S. McEwen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free