Substance dependence, family history of alcohol dependence and neuropsychological functioning in adolescence.

  • Tapert S
  • Brown S
  • 11

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Abstract

It was hypothesized that adolescent substance dependence moderates the relationship between family history of alcohol dependence and neuropsychological functioning (NF). This study compared the NF of non-abusing and alcohol- and drug-dependent adolescents (aged 13–18 yrs) with and without a family history of alcohol dependence using hierarchical multiple regressions and general factorial analyses. 101 substance-dependent adolescents were recruited and tested in inpatient alcohol and drug abuse treatment programs after 3 wks of abstinence. A matched sample of 50 non-abusing adolescents was recruited from the same communities. Information was gathered on demographics, family history, substance involvement, and conduct disorder behaviors and Ss were administered neuropsychological tests covering language, visuospatial, verbal memory, attention, and executive functioning domains. The hypothesis was supported for language and attention tests. Substance involvement interacted with family history of alcohol dependence to predict language and attention functioning. Family history negative non-abusers performed better than the other Ss. Results suggest that family history of alcohol dependence and adolescent substance use are separate risk factors for poorer NF. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Author-supplied keywords

  • Alcohol Abuse
  • Attention
  • Cognitive Ability
  • Drug Dependency
  • Family Background
  • Family History
  • Language
  • Neuropsychology
  • Verbal Memory
  • Visuospatial Ability
  • alcohol &/or drug abusing 13–18 yr old inpatients
  • substance dependence as moderator of relationship

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Authors

  • Susan F Tapert

  • Sandra A Brown

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