Sulfonamides and sulfones have been utilized for a variety of apparently unrelated disorders, such as dermatitis herpetiformis, subcorneal pustulosis, leukoclastic vasculitis, conglobate acne, pyoderma gangrenosum, and relapsing polychondritis, among others. The sulfones have a more favorable therapeutic index than the sulfonamides, and are therefore considered the most effective therapeutic agents for such dermatoses. The mechanism for this therapeutic effectiveness has not been clearly established, but it appears to be largely unrelated to antimicrobial effects, and in part, at least, may be related to their profound interference with the myeloperoxidase-H2O2-halide-mediated, cytotoxic system in the polymorphonuclear leukocyte. All sulfapyridine-and sulfone-type drugs may be associated with serious adverse reactions, and patients being treated with such preparations must be closely monitored.
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