Supercritical rosemary extracts, their antioxidant activity and effect on hepatic tumor progression.

  • Vicente G
  • Molina S
  • Gonzalez-Vallinas M
 et al. 
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Abstract

The use of supercrit. fluid technol. as an innovative technol. to ext. bioactive compds. has grown considerably in recent decades. Particularly, the recovery of antioxidants from different herbs is a matter of continuous research and development. Antioxidants can protect cells against the effects of free radicals and thus, play an important role in heart illness, cancer and other diseases. Rosemary (Rosmarinus officinalis L.) has been recognized as one of the Lamiaceae plant with many important biol. activities. Particularly, large antioxidant power has been recognized in rosemary and main substances related with this activity were the phenolic diterpenes such as carnosol, rosmanol, carnosic acid, Me carnosate, and phenolic acids such as the rosmarinic and caffeic acids. Moreover, carnosic acid and carnosol are recognized as the most abundant antioxidants present in rosemary. In this work, supercrit. fluid technol. was applied to produce rosemary exts. with different compns. and thus, with different bioactivity properties. Selected exts., from the variety of samples obtained, were used to study the capability of rosemary supercrit. exts. to inhibit the proliferation of human liver carcinoma cells. These exts. showed a dose-dependent effect on inhibiting the proliferation of human hepatoma cells. Moreover, obsd. citostaticity appeared to be significantly influenced by their different compn., suggesting a relevant role of the technol. to produce the exts. and the consequently obtained compns. on the potential antitumoral activity of rosemary. [on SciFinder(R)]

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Authors

  • Gonzalo Vicente

  • Susana Molina

  • Margarita Gonzalez-Vallinas

  • Monica R Garcia-Risco

  • Tiziana Fornari

  • Guillermo Reglero

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