Synthesis and antitumour activity of new muricatacin and goniofufurone analogues

  • Popsavin V
  • Srećo B
  • Krstić I
 et al. 
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Abstract

A divergent approach to the 7-oxa (-)-muricatacin analogue 2, the corresponding (+)-enantiomer ent-2 and the furanolactone 3 is reported starting from d-xylose. The resulting lactones have shown a potent and selective in vitro cytotoxicity against certain human neoplastic cell lines. © 2006 Elsevier Masson SAS. All rights reserved.

Author-supplied keywords

  • Antitumour lactones
  • Bioisostere
  • Goniofufurone analogue
  • Muricatacin analogues
  • Wittig reaction

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