Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

  • Dang Q
  • Brown B
  • Van Poelje P
 et al. 
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Abstract

A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1- naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives.

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Authors

  • Qun Dang

  • Brian S. Brown

  • Paul D. Van Poelje

  • Timothy J. Colby

  • Mark D. Erion

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