Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications

  • Driesschaert B
  • Charlier N
  • Gallez B
 et al. 
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Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations. © 2008 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • EPR
  • Ester aminolysis
  • Oximetry
  • TAM
  • Tetrathiatriarylmethyl
  • Trityl radical

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  • Benoît Driesschaert

  • Nicolas Charlier

  • Bernard Gallez

  • Jacqueline Marchand-Brynaert

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