Synthetic medicinal chemistry in chagas' disease: Compounds at the final stage of "hit-to-lead" phase

  • Cerecetto H
  • González M
  • 36


    Mendeley users who have this article in their library.
  • 43


    Citations of this article.


Chagas’ disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the “active-to-hit” stage. However, only a more limited number of these have been studied in vivo in models of Chagas’ disease. Herein, we survey some of the cantidates able to surpass the “hit-to-lead” stage discussing their limitations or merit to enter in clinical trials in the short term.

Author-supplied keywords

  • "hit-to-lead"
  • Chagas' disease
  • Drug-likeness

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free