Chagas' disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the "active-to-hit" stage. However, only a more limited number of these have been studied in vivo in models of Chagas' disease. Herein, we survey some of the cantidates able to surpass the "hit-to-lead" stage discussing their limitations or merit to enter in clinical trials in the short term. © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. © 2010 by the authors.
CITATION STYLE
Cerecetto, H., & González, M. (2010). Synthetic medicinal chemistry in chagas’ disease: Compounds at the final stage of “hit-to-lead” phase. Pharmaceuticals. MDPI AG. https://doi.org/10.3390/ph3040810
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