Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
CITATION STYLE
Olsson, B., Andersson, P. O., Jernås, M., Jacobsson, S., Carlsson, B., Carlsson, L. M. S., & Wadenvik, H. (2003). T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nature Medicine, 9(9), 1123–1124. https://doi.org/10.1038/nm921
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