Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis

  • Martorelli De Lima A
  • Cury C
  • Palioto D
 et al. 
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Martorelli de Lima AF, Cury CC, Palioto DB, Duro AM, Da Silva RC, Wolff LF: Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis. J Clin Periodontol 2004; 31: 648-653. doi: 10.1111/j.1600-051X.2004.00576.x. Copyright Blackwell Munksgaard, 2004. Abstract Objectives: The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients. Material and methods: Twenty-two paired periodontal defects >/=5.0 mm were treated in 11 patients (35-55 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyclate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and F tests. Results: Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (p

Author-supplied keywords

  • Article
  • GEL
  • Periodontitis
  • ROOT
  • clinical parameters
  • doxycycline-hyclate
  • local delivery
  • methods
  • periodontal therapy
  • scaling

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  • A F Martorelli De Lima

  • C C Cury

  • D B Palioto

  • A M Duro

  • R C Silva

  • L F Wolff

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