Titanium dioxide nanoparticles: Some aspects of toxicity/focus on the development

  • Rollerova E
  • Tulinska J
  • Liskova A
 et al. 
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Abstract

Nanosized titanium dioxide (TiO2 ) particles belong to the most widely manufactured nanoparti- cles (NPs) on a global scale because of their photocatalytic properties and the related surface eff ects. TiO2 NPs are in the top fi ve NPs used in consumer products. Ultrafi ne TiO2 is widely used in the number of applications, including white pigment in paint, ceramics, food additive, food packag- ing material, sunscreens, cosmetic creams, and, component of surgical implants. Data evidencing rapid distribution, slow or ineff ective elimination, and potential long-time tissue accumulation are especially important for the human risk assessment of ultrafi ne TiO2 and represent new challenges to more responsibly investigate potential adverse eff ects by the action of TiO2 NPs considering their ubiquitous exposure in various doses. Transport of ultrafi ne TiO2 particles in systemic circu- lation and further transition through barriers, especially the placental and blood-brain ones, are well documented. Th erefore, from the developmental point of view, there is a raising concern in the exposure to TiO2 NPs during critical windows, in the pregnancy or the lactation period, and the fact that human mothers, women and men in fertile age and last but not least children may be exposed to high cumulative doses. In this review, toxicokinetics and particularly toxicity of TiO2 NPs in relation to the developing processes, oriented mainly on the development of the central nervous system, are discussed

Author-supplied keywords

  • Blood brain barrier
  • Developmental toxicity
  • Nanomaterials
  • Nanoparticles
  • Nanotoxicity
  • Placental barrier
  • Reproductive toxicity
  • Titanium dioxide

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