Towards a multidisciplinary and integrated strategy in the assessment of adverse health effects related to air pollution: The case study of Cracow (Poland) and asthma

  • Oudinet J
  • Meline J
  • Chehmicki W
 et al. 
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Complex interaction between anthropogenic activities, air quality and
human health in urban areas, such as in Cracow sustains the need for the
development of an interdisciplinary and integrated risk-assessment
methodology. In such purpose, we propose a pilot study performed on
asthmatics and based on a combined use of a biomarker, such as
metallothionein 2A (MT-2A) in the characterization of human exposure to
one or a mixture of pollutants and of Geographical Information Systems
(G.I.S.) which integrates climatic and urban anthropogenic parameters in
the assessment of spatio-temporal dispersion of air pollutants.
Considering global incidence of air pollution on asthma and on
peripheral blood lymphocytes MT-2A expression should provide a
complementary information on biological risks linked to urban
anthropogenic activities. Such study would help for the establishment of
a sustainable development in urban areas that can maintain the integrity
of air quality and preserve human health. (c) 2005 Elsevier Ltd. All
rights reserved.

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  • J P Oudinet

  • J Meline

  • W Chehmicki

  • M Sanak

  • D W Magdalena

  • J P Besancenot

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