TRAIL: A molecule with multiple receptors and control mechanisms

  • Griffith T
  • Lynch D
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Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

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  • Thomas S. Griffith

  • David H. Lynch

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