Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.
CITATION STYLE
Griffith, T. S., & Lynch, D. H. (1998). TRAIL: A molecule with multiple receptors and control mechanisms. Current Opinion in Immunology, 10(5), 559–563. https://doi.org/10.1016/S0952-7915(98)80224-0
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