Using 31P-magnetic resonance spectroscopy during and after exercise, we studied whether forearm metabolic responses to exercise were improved by 1 mo of training in 10 males with heart failure. In the control (untrained) arm, there were no changes in any of the measured variables. In the trained arm, maximal voluntary contraction increased 6% (P = 0.05). During incremental exercise, duration increased 19% (P < 0.05) and submaximal responses improved for pH (6.78 ± 0.13 pretraining vs. 6.85 ± 0.17 posttraining; P < 0.01) and PCr/(PCr + P(i)) (where PCr is phosphocreatine; 0.48 ± 0.09 pretraining vs. 0.52 ± 0.07 posttraining; P < 0.01). The PCr resynthesis rate increased by 48% (P < 0.01), and estimated effective maximal rate of mitochondrial ATP synthesis increased by 37% (P < 0.05). Endurance exercise duration increased by 67% (P < 0.01), and submaximal levels of PCr/(PCr + P(i)) (P < 0.05) and pH (P = 0.07) improved. The PCr resynthesis rate (P < 0.01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0.05) also improved. These findings document that impaired oxidative capacity of skeletal muscle can be improved by local muscle training in heart failure, which is compatible with the hypothesis that a part of the abnormality present in heart failure may be due to inactivity.
CITATION STYLE
Stratton, J. R., Dunn, J. F., Adamopoulos, S., Kemp, G. J., Coats, A. J. S., & Rajagopalan, B. (1994). Training partially reverses skeletal muscle metabolic abnormalities during exercise in heart failure. Journal of Applied Physiology, 76(4), 1575–1582. https://doi.org/10.1152/jappl.1994.76.4.1575
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