Training partially reverses skeletal muscle metabolic abnormalities during exercise in heart failure.

  • Stratton J
  • Dunn J
  • Adamopoulos S
 et al. 
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Abstract

Using 31P-magnetic resonance spectroscopy during and after exercise, we studied whether forearm metabolic responses to exercise were improved by 1 mo of training in 10 males with heart failure. In the control (untrained) arm, there were no changes in any of the measured variables. In the trained arm, maximal voluntary contraction increased 6% (P = 0.05). During incremental exercise, duration increased 19% (P < 0.05) and submaximal responses improved for pH (6.78 +/- 0.13 pretraining vs. 6.85 +/- 0.17 posttraining; P < 0.01) and PCr/(PCr+Pi) (where PCr is phosphocreatine; 0.48 +/- 0.09 pretraining vs. 0.52 +/- 0.07 posttraining; P < 0.01). The PCr resynthesis rate increased by 48% (P < 0.01), and estimated effective maximal rate of mitochondrial ATP synthesis increased by 37% (P < 0.05). Endurance exercise duration increased by 67% (P < 0.01), and submaximal levels of PCr/(PCr+Pi) (P < 0.05) and pH (P = 0.07) improved. The PCr resynthesis rate (P < 0.01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0.05) also improved. These findings document that impaired oxidative capacity of skeletal muscle can be improved by local muscle training in heart failure, which is compatible with the hypothesis that a part of the abnormality present in heart failure may be due to inactivity.

Author-supplied keywords

  • Adenosine Triphosphate
  • Adenosine Triphosphate: biosynthesis
  • Adenosine Triphosphate: metabolism
  • Adult
  • Aged
  • Forearm
  • Forearm: physiology
  • Heart Failure
  • Heart Failure: metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Muscle Contraction
  • Muscle Contraction: physiology
  • Muscles
  • Muscles: metabolism
  • Phosphocreatine
  • Phosphocreatine: metabolism
  • Physical Education and Training
  • Physical Endurance
  • Physical Endurance: physiology

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Authors

  • J R Stratton

  • J F Dunn

  • S Adamopoulos

  • G J Kemp

  • a J Coats

  • B Rajagopalan

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