Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis

  • Makkar R
  • Fontana G
  • Jilaihawi H
 et al. 
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Background Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known. Methods We randomly assigned patients to transfemoral TAVR or to standard therapy (which often included balloon aortic valvuloplasty). Data on 2-year outcomes were analyzed. Results A total of 358 patients underwent randomization at 21 centers. The rates of death at 2 years were 43.3% in the TAVR group and 68.0% in the standard-therapy group (P

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  • Raj R. Makkar

  • Gregory P. Fontana

  • Hasan Jilaihawi

  • Samir Kapadia

  • Augusto D. Pichard

  • Pamela S. Douglas

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