Trends in usage of alternative antiplatelet therapy after stroke and transient ischemic attack

  • Hills N
  • Johnston S
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BACKGROUND AND PURPOSE The effects of alternative antiplatelet agents such as clopidogrel and dipyridamole have been studied in clinical trials and heavily marketed. Because public data on their usage are limited, we examined trends in their prescription after stroke and transient ischemic attack to assess the impact of marketing and trial results. METHODS Between 2001 and 2005, 85 US hospitals prospectively enrolled all patients admitted with ischemic stroke or transient ischemic attack into a registry designed for quality improvement (Ethos). Data on rates of antiplatelet medication usage at discharge were examined over time, and trends were evaluated by the Mantel-Haenszel test. RESULTS Among 18 020 patients included during the 4-year period, 89% were discharged on antithrombotic medication. Between the first quarter of 2001 and the first quarter of 2004, prescription of clopidogrel-aspirin doubled (P

Author-supplied keywords

  • Antiplatelet agents
  • Antithrombotics
  • Clinical trials
  • Secondary prevention
  • Stroke
  • Transient ischemic attack

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  • Nancy K. Hills

  • S. Claiborne Johnston

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