Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors. © 2010 Elsevier B.V.
CITATION STYLE
Torchilin, V. (2011, March 18). Tumor delivery of macromolecular drugs based on the EPR effect. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2010.03.011
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