Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-β-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11′-O-β-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC50 values in the range of 5 μM, whereas compound 4 was approximately 10-fold less active.
CITATION STYLE
Waffo-Teguo, P., Lee, D., Cuendet, M., Mërillon, J. M., Pezzuto, J. M., & Douglas Kinghorn, A. (2001). Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. Journal of Natural Products, 64(1), 136–138. https://doi.org/10.1021/np000426r
Mendeley helps you to discover research relevant for your work.