DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order oλ- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium bistability between two different migration states, a slow one and a fast one. The latter can also be observed experimentally under appropriate conditions. © 2005 The American Physical Society.
CITATION STYLE
Streek, M., Schmid, F., Duong, T. T., Anselmetti, D., & Ros, A. (2005). Two-state migration of DNA in a structured microchannel. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 71(1). https://doi.org/10.1103/PhysRevE.71.011905
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