Two-state migration of DNA in a structured microchannel

  • Streek M
  • Schmid F
  • Duong T
 et al. 
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DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order of - and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium phase transition between two different migration states, a slow one and a fast one, which can also be observed experimentally under appropriate conditions.

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  • Martin Streek

  • Friederike Schmid

  • Thanh Tu Duong

  • Dario Anselmetti

  • Alexandra Ros

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