Valvular interstitial cells suppress calcification of valvular endothelial cells

  • Hjortnaes J
  • Shapero K
  • Goettsch C
 et al. 
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Abstract

Background: Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. We previously proposed that valvular endothelial cells (VECs) replenish injured adult valve leaflets via endothelial-to-mesenchymal transformation (EndMT); however, whether EndMT contributes to valvular calcification is unknown. We hypothesized that aortic VECs undergo osteogenic differentiation via an EndMT process that can be inhibited by valvular interstitial cells (VICs). Approach and results: VEC clones underwent TGF-β1-mediated EndMT, shown by significantly increased mRNA expression of the EndMT markers α-SMA (5.3±1.2), MMP-2 (13.5±0.6) and Slug (12±2.1) (p

Author-supplied keywords

  • Calcific aortic valve disease
  • Calcification
  • Endothelial-to-mesenchymal transformation
  • Valvular endothelial cells
  • Valvular interstitial cells

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Authors

  • Claudia GoettschRheinisch-Westfälische Technische Hochschule Aachen

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  • Jesper Hjortnaes

  • Kayle Shapero

  • Joshua D. Hutcheson

  • Joshua Keegan

  • Jolanda Kluin

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