Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese.

  • Huang Y
  • Huang M
  • Yang S
 et al. 
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Abstract

INTRODUCTION: Results of several studies have indicated that the variation of c.-3279T>G in the UDP-glucuronosyltransferase (UGT)1A1 gene could be a further factor for the development of hyperbilirubinemia. However, this variant has not been reported in the Taiwanese population. MATERIALS & METHODS: PCR-restriction fragment length polymorphism was utilized to determine variants at nucleotides -3279 (*60), -53 (*28) and 211 (*6) in the UGT1A1 gene for 178 Taiwanese hyperbilirubinemic patients and 200 controls. RESULTS: A total of ten and nine diplotypes were observed in the hyperbilirubinemic patients and controls, respectively. Subjects possessing diplotypes of compound haplotypes (*60/*28, *60/*6, *1/*60 plus *1/*28 plus *1/*6); *60/*60; *60/*60 plus 1/*28 and *6/*6 were significantly related to hyperbilirubinemia development, with an odds ratio of 7.83-188.00 (p = 0.012 approximately G variant is a further factor for the development of hyperbilirubinemia. Our results also demonstrate that possessing the *60/*60 plus *28/*28 diplotype in the UGT1A1 gene is a determinant of relatively higher bilirubin values amongst hyperbilirubinemic patients.

Author-supplied keywords

  • Adult
  • Bilirubin
  • Bilirubin: genetics
  • Female
  • Genetic
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genetic Variation: genetics
  • Genetic: genetics
  • Glucuronosyltransferase
  • Glucuronosyltransferase: genetics
  • Humans
  • Hyperbilirubinemia
  • Hyperbilirubinemia: enzymology
  • Hyperbilirubinemia: epidemiology
  • Hyperbilirubinemia: genetics
  • Male
  • Middle Aged
  • Polymorphism
  • Taiwan
  • Taiwan: epidemiology

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Authors

  • Yang-Yang Huang

  • May-Jen Huang

  • Sieng-Sien Yang

  • Hsiu-Chen Teng

  • Ching-Shan Huang

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