Venous thromboembolism and risk of cancer in patients with diabetes mellitus

  • D.H. C
  • E. H
  • R.W. T
 et al. 
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Abstract

Aim Venous thromboembolism (VTE) has long been regarded as a marker of underlying malignancy in the general population. Patients with diabetes mellitus are at increased risk of developing VTE, but it is unclear whether VTE in diabetes patients is also a harbinger of occult cancer. Methods From Danish medical health databases, we identified all diabetes patients (N = 8783) with a first-time diagnosis of VTE during 1978-2011. We followed the patients until a first-time diagnosis of cancer, emigration, death, or study end, whichever came first. We calculated one-year absolute cancer risk and overall and site-specific standardized incidence ratios (SIRs) for cancer based on national cancer incidence. Results During the total study period 878 cancers were observed. The one-year absolute cancer risk was 4.1% and the corresponding SIR was 3.28 (95% confidence interval [CI]: 2.94-3.64). The highest SIRs were observed for cancers of the gallbladder and biliary tract (SIR 13.59; 6.77-24.31), the pancreas (SIR 10.16; 6.85-14.50), the ovary (SIR 9.85; 5.63-16.00), and the liver (SIR 9.39; 4.30-17.84). After the first year of follow-up, the overall cancer SIR associated with VTE and diabetes decreased to 1.05 (95% CI: 0.97-1.15). Conclusions VTE may be a marker of underlying cancer in patients with diabetes mellitus. Copyright © 2016 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • *cancer risk
  • *diabetes mellitus
  • *diabetic patient
  • *insulin dependent diabetes mellitus
  • *neoplasm
  • *non insulin dependent diabetes mellitus
  • *venous thromboembolism
  • Denmark
  • adult
  • aged
  • article
  • basal cell carcinoma/ep [Epidemiology]
  • bile duct cancer/ep [Epidemiology]
  • bladder cancer/ep [Epidemiology]
  • brain cancer/ep [Epidemiology]
  • breast cancer/ep [Epidemiology]
  • bronchus cancer/ep [Epidemiology]
  • cancer incidence
  • cancer risk
  • cancer susceptibility
  • cohort analysis
  • colon cancer/ep [Epidemiology]
  • confidence interval
  • data base
  • death
  • diabetic patient
  • diagnosis
  • esophagus cancer/ep [Epidemiology]
  • female
  • follow up
  • gallbladder cancer
  • gallbladder cancer/ep [Epidemiology]
  • human
  • intestine cancer/ep [Epidemiology]
  • kidney cancer/ep [Epidemiology]
  • liver
  • liver cancer/ep [Epidemiology]
  • lung cancer/ep [Epidemiology]
  • lymphatic leukemia/ep [Epidemiology]
  • major clinical study
  • male
  • melanoma/ep [Epidemiology]
  • metastasis/ep [Epidemiology]
  • nonhodgkin lymphoma/ep [Epidemiology]
  • occult cancer
  • ovary
  • ovary cancer/ep [Epidemiology]
  • pancreas
  • pancreas cancer/ep [Epidemiology]
  • population
  • priority journal
  • prostate cancer/ep [Epidemiology]
  • rectum cancer/ep [Epidemiology]
  • risk assessment
  • skin cancer/ep [Epidemiology]
  • standardized incidence ratio
  • stomach cancer/ep [Epidemiology]
  • trachea cancer/ep [Epidemiology]
  • uterus cancer/ep [Epidemiology]

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Authors

  • Christensen D.H.

  • Horvath-Puho E.

  • Thomsen R.W.

  • Knudsen S.T.

  • Dekkers O.

  • Prandoni P.

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