In vitro sortase A inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens

  • Oh I
  • Yang W
  • Chung S
 et al. 
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Abstract

A series of flavonoids (1-14) was isolated from the roots of Sophora flavescens. We evaluated their ability to inhibit both microbial growth and sortase A, an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus. Most prenylated flavonoids (7-13) displayed potent inhibitory activity against gram-positive and gram-negative bacteria except E. coli, with minimum inhibitory concentrations values ranging from 4.40 to 27.7 μM, and weak or no activity against fungal strains tested. Kurarinol (6) was a potent inhibitor of sortase A, with an IC(50) value of 107.7 ± 6.6 μM. A preliminary structure-activity relationship, including essential structural requirements, is described.

Author-supplied keywords

  • Antibacterial activity
  • Flavonoids
  • Kurarinol
  • Sophora flavescens
  • Sortase A

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Authors

  • Ikhoon Oh

  • Woo Young Yang

  • Soon Chun Chung

  • Tae Yoon Kim

  • Ki Bong Oh

  • Jongheon Shin

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