Skip to content
Journal article

In vivo small animal imaging: current status and future prospects

Kagadis G, Loudos G, Katsanos K, Langer S, Nikiforidis G ...see all

Med Phys, vol. 37, issue 12 (2010) pp. 6421-6442

  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

Medical Physics The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to commercial translation to clinical practice. Whole-body small animal imaging is a particularly elegant and cost-effective experimental platform for the timely validation and commercialization of novel agents from the bench to the bedside. Biomedical imaging is now listed along with genomics, proteomics, and metabolomics as an integral part of biological and medical sciences. Miniaturized versions of clinical diagnostic modalities, including but not limited to microcomputed tomography, micromagnetic resonance tomography, microsingle- photon-emission tomography, micropositron-emission tomography, optical imaging, digital angiog- raphy, and ultrasound, have all greatly improved our investigative abilities to longitudinally study various experimental models of human disease in mice and rodents. After an exhaustive literature search, the authors present a concise and critical review of in vivo small animal imaging, focusing on currently available modalities as well as emerging imaging technologies on one side and mo- lecularly targeted contrast agents on the other. Aforementioned scientific topics are analyzed in the context of cancer angiogenesis and innovative antiangiogenic strategies under-the-way to the clinic. Proposed hybrid approaches for diagnosis and targeted site-specific therapy are highlighted to offer an intriguing glimpse of the future. ©

Author-supplied keywords

  • digital angiography
  • hybrid imaging
  • micro-ct
  • micro-mri
  • micro-pet
  • micro-spect
  • molecular imaging
  • optical imaging
  • small animal imaging
  • ultrasound

Find this document

Authors

  • George C. Kagadis

  • George Loudos

  • Konstantinos Katsanos

  • Steve G. Langer

  • George C. Nikiforidis

Cite this document

Choose a citation style from the tabs below