White matter abnormalities in children with and at risk for bipolar disorder

  • J.A. F
  • J.L. B
  • G. P
 et al. 
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Abstract

Objectives: Diffusion tensor magnetic resonance imaging (DT-MRI) assesses the integrity of white matter (WM) tracts in the brain. Children with bipolar disorder (BPD) may have WM abnormalities that precede illness onset. To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder. Methods: Ten children with BPD, eight healthy controls (HC), and seven AR-BPD, similar in age, had MRI scans on a 1.5 Tesla GE scanner, including a standard DT-MRI sequence (T2-EPI) with 25 axial slices. Fractional anisotropy (FA) values were compared between groups to determine regions of significant difference (p

Author-supplied keywords

  • *bipolar disorder/di [Diagnosis]
  • *bipolar disorder/dt [Drug Therapy]
  • *bipolar disorder/et [Etiology]
  • *brain disease/di [Diagnosis]
  • *brain disease/dt [Drug Therapy]
  • *child psychiatry
  • *white matter
  • Diagnostic and Statistical Manual of Mental Disord
  • adolescent
  • alpha adrenergic receptor stimulating agent/dt [Dr
  • anisotropy
  • anticonvulsive agent/dt [Drug Therapy]
  • antidepressant agent/dt [Drug Therapy]
  • article
  • atomoxetine/dt [Drug Therapy]
  • benzodiazepine/dt [Drug Therapy]
  • cingulate gyrus
  • clinical article
  • controlled study
  • corpus callosum
  • diffusion tensor imaging
  • female
  • high risk population
  • human
  • human tissue
  • male
  • neuroanatomy
  • neuroleptic agent/dt [Drug Therapy]
  • nuclear magnetic resonance imaging
  • orbital cortex
  • phenotype
  • preschool child
  • priority journal
  • prognosis
  • psychologic assessment
  • risk factor
  • school child
  • statistical significance

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Authors

  • Frazier J.A.

  • Breeze J.L.

  • Papadimitriou G.

  • Kennedy D.N.

  • Hodge S.M.

  • Moore C.M.

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