X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA. Here, we review our understanding of dosage compensation and Xist function in the context of disease. © 2009 Elsevier Ltd. All rights reserved.
CITATION STYLE
Agrelo, R., & Wutz, A. (2010). X inactivation and disease. Seminars in Cell and Developmental Biology. Elsevier Ltd. https://doi.org/10.1016/j.semcdb.2009.09.017
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