Use of X-linked markers for forensic purposes.

  • Szibor R
  • Krawczak M
  • Hering S
 et al. 
  • 59

    Readers

    Mendeley users who have this article in their library.
  • 251

    Citations

    Citations of this article.

Abstract

In forensic science, X-chromosomal short tandem repeats (ChrX STRs) bear the potential to efficiently complement the analysis of other genetic markers (autosomal, Y-chromosomal or mitochondrial). We review the population genetic properties and forensic utility of selected ChrX markers, and discuss the problems and limitations arising with their practical use. Formulae required to assess the evidential power of individual markers in different contexts are summarised and applied to ChrX STRs of interest. Since linkage and linkage disequilibrium between markers affect the inferential interpretation of genotype data, practically relevant information regarding the co-localisation and haplotypic association of ChrX STRs is provided. Finally, two examples of complex kinship testing are presented which serve to highlight the particular importance of ChrX STRs for solving deficiency cases and cases involving blood relatives.

Author-supplied keywords

  • Chromosome Mapping
  • Chromosomes, Human, X
  • Chromosomes, Human, X: genetics
  • DNA Fingerprinting
  • Female
  • Genetic Markers
  • Genetic Markers: genetics
  • Haplotypes
  • Humans
  • Male
  • Paternity
  • Sex Chromosome Aberrations
  • Sex Factors
  • Tandem Repeat Sequences

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • R Szibor

  • M Krawczak

  • S Hering

  • J Edelmann

  • E Kuhlisch

  • D Krause

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free