Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

  • Anver S
  • Roguev A
  • Zofall M
 et al. 
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Abstract

Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome. Xap5 is highly conserved across eukaryotes, and a plant homolog rescues xap5 mutant yeast. We propose that Xap5 likely functions as a chromatin regulator in diverse organisms.

Author-supplied keywords

  • aberrant transcripts
  • chromatin modification
  • epigenetics
  • functional
  • genomics
  • long terminal
  • repeats
  • subject categories chromatin
  • transcription
  • transcriptional repression
  • transposable elements

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Authors

  • Shajahan Anver

  • Assen Roguev

  • Martin Zofall

  • Nevan J Krogan

  • Shiv I S Grewal

  • Stacey L Harmer

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