Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

  • Anver S
  • Roguev A
  • Zofall M
 et al. 
  • 28


    Mendeley users who have this article in their library.
  • 7


    Citations of this article.


Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome. Xap5 is highly conserved across eukaryotes, and a plant homolog rescues xap5 mutant yeast. We propose that Xap5 likely functions as a chromatin regulator in diverse organisms.

Author-supplied keywords

  • aberrant transcripts
  • chromatin modification
  • epigenetics
  • functional
  • genomics
  • long terminal
  • repeats
  • subject categories chromatin
  • transcription
  • transcriptional repression
  • transposable elements

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Shajahan Anver

  • Assen Roguev

  • Martin Zofall

  • Nevan J Krogan

  • Shiv I S Grewal

  • Stacey L Harmer

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free