Zoom zoom: Racing CARs for multiple myeloma

  • Maus M
  • June C
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Abstract

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.

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Authors

  • Marcela V. Maus

  • Carl H. June

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