Antihistaminic effect of Moringa oleifera seed extract

Abstract

To evaluate the antihistaminic activity of Moringa oleifera (Moringaceae) to validate its traditional use, The antihistaminic activity of ethanolic seed extract of Moringa oleifera was evaluated on horse serum and triple antigen induced active anaphylaxis Wistar albino rats. Ethanolic seed extract (500 mg/kg body weight) significantly decreases histamine secretion and de-granulation of mast cells in rats (09.35±2.32). Phytochemical study revealed the presence of steroid saponins, alkaloids, flavonoid and glycoside. The glycoside saponin was reported to possess mast cell degranulation inhibiting and antihistaminic activity.