The ABO blood group system is known to act as a major transplantation barrier in primates. Different primate species share the presence of A and B antigens. The polymorphism of the macaque ABO blood group genes was analyzed by cloning and sequencing the exon 7 region. In the case of the rhesus macaque (Macaca mulatta) and cynomolgus monkey (Macaca fascicularis) we were able to identify ABO blood group gene segments which cluster into two lineages, namely: *A/*O1 and *B. In addition allelic variation was observed. The 2 amino acid replacements at positions 266 and 268, which are thought to be crucial for A or B transferase activity, could be confirmed for both macaque species. Comparison of primate sequences shows that A and B reactivity was generated independently from each other in the hominoids and Old World monkey lineages. Hence, the primate A and B blood group genes are subject to convergent evolution. Copyright © Munksgaard 1998. All rights reserved.
CITATION STYLE
Doxiadis, G. G. M., Otting, N., Antunes, S. G. M., De Groot, N. G., Harvey, M., Doxiadis, I. I. N., … Bontrop, R. E. (1998). Characterization of the ABO blood group genes in macaques: Evidence for convergent evolution. Tissue Antigens, 51(4 I), 321–326. https://doi.org/10.1111/j.1399-0039.1998.tb02970.x
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