Skip to content

Characterization of antibody responses against a neutralizing epitope on the glycoprotein E2 of classical swine fever virus

by Y. Qi, L. C. Liu, B. Q. Zhang, Z. Shen, J. Wang, Y. H. Chen
Archives of Virology ()
Get full text at journal


The sequence TAVSPTTLR is a conserved and linear neutralizing epitope on the glycoprotein E2 of classical swine fever virus. In this study, TAVSPTTLR-directed antibodies, induced either by virions or by an epitope-focused immunogen, were characterized. The results revealed that despite the same epitope specificity, the antibodies induced by different immunogens varied significantly both in the neutralizing test and in binding inhibition assays. This suggests that the protective immunity induced by this epitope is due to more than simply the epitope specificity and that this epitope might need essential contributions from its flanking context to induce functional epitope-specific antibodies.

Cite this document (BETA)

Readership Statistics

3 Readers on Mendeley
by Discipline
67% Agricultural and Biological Sciences
33% Medicine and Dentistry
by Academic Status
67% Researcher
33% Student > Ph. D. Student

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in