Fluorescence in situ hybridization (FISH) is a method of using fluorescent probes to detect specific nucleic acid sequences within cells and their location. It can be used to detect a variety of cytogenetic variations, including chromosomal deletions, amplification, and translocation. As a classical cytogenetic method, FISH is widely used in prenatal diagnosis as well as the detection of tumors and infections. FISH is a combination of cytogenetics and molecular biology. It is a bridge between cytogenetics and molecular biology and belongs to molecular cytogenetics. FISH is fast, safe, with high sensitivity, and is easy to use.
CITATION STYLE
Hu, M., & Wu, W. (2021). Fluorescence In Situ Hybridization. In Clinical Molecular Diagnostics (pp. 405–411). Springer Nature. https://doi.org/10.1007/978-981-16-1037-0_29
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