The aim of this study was to assess the prevalence of increased thyroid-stimulating hormone (TSH) levels (subclinical or undiagnosed hypothyroidism) in a representative sample of a community-living elderly population and to examine the relationships with cognitive functions and depressive symptoms. An epidemiological study was made of a cohort of 2792 subjects over 65 years of age. A blood sample was obtained from 425 volunteers of this cohort and assayed for TSH. Every subject participating in the study was interviewed and given a battery of neuropsychological tests by a psychologist. Three hundred and eighty-one subjects (89.7%) had normal TSH levels; 18 subjects (4.2%) had TSH lower than 0.4 microU/ml, associated in two of them with hyperthyroxinaemia. Twenty-six subjects (6.1%) had increased TSH levels, associated in 18 of them with a normal free thyroxine level and in eight with a low free thyroxine level. Increased TSH levels were significantly linked with female sex and with the presence of symptoms of depression on the CES-D scale but not with impairment of cognitive function.
CITATION STYLE
G., M., J.F., D., A., D., P., B.-G., L., L., M.J., L., … Latapie, J. L. (1995). The PAQUID survey and correlates of subclinical hypothyroidism in elderly community residents in the southwest of France. Age and Ageing, 24(3), 235–241. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L25155820 http://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=00020729&id=doi:&atitle=The+PAQUID+survey+and+correlates+of+subclinical+hypothyroidism+in+elderly+community+residents+in+th
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