A genetically engineered Eimeria tenella antigen (GX3262), produced as a fusion protein with β-galactosidase and identified with a monoclonal antibody, induced partial but significant protection in young broiler chickens against experimental E. tenella and Eimeria acervulina infections. The antigen appears to share a T-helper cell epitope with the parasite as evidenced by (a) booster inoculation with either the recombinant antigen or with a small number of liver oocysts enhanced the protective immunity in GX3262 primed chickens, and (b) ability of the antigen to induce in vitro stimulation of T-cells from chickens immunized with antigen or parasite. These observations suggest the feasibility of a single vaccination of 1 or 2-day-old broilers with GX3262 to induce an acceptable degree of protective immunity. The implications of the observations reported here are far reaching in terms of a practical coccidiosis vaccine for poultry, and show for the first time that 1-day-old broiler chickens can be efficiently vaccinated with a recombinant antigen against one or more species of Eimeria. © 1992.
CITATION STYLE
Bhogal, B. S., Miller, G. A., Anderson, A. C., Jessee, E. J., Strausberg, S., McCandliss, R., … Strausberg, R. L. (1992). Potential of a recombinant antigen as a prophylactic vaccine for day-old broiler chickens against Eimeria acervulina and Eimeria tenella infections. Veterinary Immunology and Immunopathology, 31(3–4), 323–335. https://doi.org/10.1016/0165-2427(92)90019-M
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