Proinflammatory and antiinflammatory cytokines and bone mineral density in psoriatic arthritis

Abstract

We determined proinflammatory (IL-1, IL-6, and TNF-a) and antiinflammatory (IL-4 and IL-13) cytokines in serum and synovial articular fluid at 27 (15 = m, 12 = f) patients with psoriatic arthritis (Casper criteria). The age ranged between 27 and 50 years. Normal subjects were 20 volunteers aged 30 years with no forms of joint, infectious, neoplastic, or autoimmune diseases. The cytokines were determined by the immunoenzimatique ELISA sandwich technique. The bone mineral density was performed by the DEXA method (dual-energy X-ray absorptiometry) at the lumbar level of the vertebral column (L2-L4); osteopenia considered at a score of -1, -2 SD and osteoporosis at a score