The alkaloid lennoxamine (1) was synthesized by transannular cyclization of a 10-membered lactam obtained by intramolecular addition of an aryl radical to a (trimethylsilyl)acetylene. The isoindolo[1,2-b][3]benzazepine skeleton present in lennoxamine was also obtained by means of regioselective 7-endo-trig radical cyclization of methylenephthalimidines.
CITATION STYLE
Rodríguez, G., Cid, M. M., Saá, C., Castedo, L., & Domínguez, D. (1996). A radical cyclization approach to isoindolobenzazepines. Synthesis of lennoxamine. Journal of Organic Chemistry, 61(8), 2780–2782. https://doi.org/10.1021/jo952113k
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