Skip to content

The role of histone acetylation in age-associated memory impairment and Alzheimer's disease

by Roman Manuel Stilling, Andr?? Fischer
Neurobiology of Learning and Memory ()
Get full text at journal

Abstract

Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for cognitive function. With a specific focus on histone acetylation, we will discuss recent research in the field of epigenetic mechanisms of learning and memory. We will also specifically address the role of histone acetylation in age-associated memory impairment and Alzheimer's disease and ask the question why targeting the epigenome could be a suitable strategy for neuroprotection and neuroregeneration. ?? 2011 Elsevier Inc.

Cite this document (BETA)

Readership Statistics

82 Readers on Mendeley
by Discipline
 
65% Agricultural and Biological Sciences
 
10% Medicine and Dentistry
 
6% Neuroscience
by Academic Status
 
21% Researcher
 
20% Student > Ph. D. Student
 
20% Student > Master
by Country
 
4% United States
 
1% Mexico
 
1% Ireland

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in